"Multifunctional Nanoparticles in Nanomedicine".
Prof Mamoun Muhammed of Royal Institute of Technology (KTH), Stockholm, Sweden will delve on major breakthroughs with smart drug delivery systems, bio‐diagnostics and early discovery of diseases, treatment of functional disorder, improved implants, visualization of cells, tissues, or organs, and targeting tissues and organ for regeneration and repairs
Venue: Room 106, Chalerm Prakiat Building, ISE, Asian Institute of Technology
Date : August 10, 2009
Time: 13:30‐14:30 hrs
Abstract
The merger of Nanotechnology and medical science offers truly novel solutions and unprecedented approaches for treating
diseases and biological disorders. Major breakthroughs are within smart drug delivery systems, bio‐diagnostics and early discovery of diseases, treatment of functional disorder, improved implants, visualization of cells, tissues, or organs, and targeting tissues and organ for regeneration and repairs, etc.
Multifunctional nanoparticles may be constructed of biocompatible matrix which can vary in size from few tens to few hundreds of nanometers. Several components can be incorporated into the nanoparticles‐matrix to achieve specific functions; e. g., reporters or visualization agents (MRI contrast agents, quantum dots) and superparamagnetic nanoparticles
which can be used for magnetic targeting, heat generation, or localization of the nanoparticles to deliver their payload (drugs, genes, DNA) to given organ or tissues. More complex systems may also include components sensitive to external environment; e.g. temperature, pH, magnetic field, etc. The surface outer layer of the nanoparticles is constructed to be a conjugation platform to which several other molecules can be attached; e.g. targeting peptides, fluorescence compounds, etc., whereas the residual surfaces should be blocked in order to avoid undesirable binding to other molecules in the
biological systems.